Blar i forfatter "Bjørkøy, Geir"

Viser treff 1-8 av 8

    • Discovery of a new marker to identify myeloid cells associated with metastatic breast tumours 

      Bokil, Ansooya Avinash; Børkja, Mathieu; Wolowczyk, Camilla Izabel; Lamsal, Apsana; Prestvik, Wenche S.; Nonstad, Unni; Pettersen, Kristine; Andersen, Sonja Benedikte; Bofin, Anna M.; Bjørkøy, Geir; Hak, Sjoerd; Giambelluca, Miriam Soledad (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-18)
      Background: Myeloid cells play an essential role in cancer metastasis. The phenotypic diversity of these cells during cancer development has attracted great interest; however, their functional heterogeneity and plasticity have limited their role as prognostic markers and therapeutic targets. <p><p>Methods: To identify markers associated with myeloid cells in metastatic tumours, we compared transcriptomic ...

    • A highly selective purine-based inhibitor of CSF1R potently inhibits osteoclast differentiation 

      Aarhus, Thomas Ihle; Eickhoff, Jan; Klebl, Bert; Unger, Anke; Boros, Johanna; Choidas, Axel; Zischinsky, Mia-Lisa; Wolowczyk, Camilla Izabel; Bjørkøy, Geir; Sundby, Eirik; Hoff, Bård Helge (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-28)
      The colony-stimulating factor 1 receptor (CSF1R) plays an important role in the regulation of many inflammatory processes, and overexpression of the kinase is implicated in several disease states. Identifying selective, smallmolecule inhibitors of CSF1R may be a crucial step toward treating these disorders. Through modelling, synthesis, and a systematic structure-activity relationship study, we ...

    • Metabolic biomarkers for response to PI3K inhibition in basal-like breast cancer 

      Moestue, Siver Andreas; Dam, Cornelia Gerarda; Gorad, Saurabh Sayajirao; Kristian, Alexandr; Bofin, Anna M.; Mælandsmo, Gunhild; Engebråten, Olav; Gribbestad, Ingrid S; Bjørkøy, Geir (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Introduction: The phosphatidylinositol 3-kinase (PI3K) pathway is frequently activated in cancer cells through numerous mutations and epigenetic changes. The recent development of inhibitors targeting different components of the PI3K pathway may represent a valuable treatment alternative. However, predicting efficacy of these drugs is challenging, and methods for therapy monitoring are needed. ...

    • A Novel Truncated Form of Nephronectin Is Present in Small Extracellular Vesicles Isolated from 66cl4 Cells 

      Toraskar, Jimita Prashant; Norvoll Magnussen, Synnøve; Hagen, Lars; Sharma, Animesh; Hoang, Linh; Bjørkøy, Geir; Svineng, Gunbjørg; Steigedal, Tonje S. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-01)
      Extracellular vesicles are emerging as biomarkers in breast cancer. Our recent report suggested that an intracellular granular staining pattern of the extracellular matrix protein nephronectin (NPNT) in breast tumor sections correlated with a poor prognosis. Furthermore, the results showed that NPNT is localized in extracellular vesicles derived from mouse breast cancer cells. In this study, we ...

    • Opposite and dynamic regulation of the interferon response in metastatic and non-metastatic breast cancer 

      Lamsal, Apsana; Andersen, Sonja Benedikte; Johansson, Ida; Vietri, Marina; Bokil, Ansooya Avinash; Kurganovs, Natalie Jayne; Rylander, Felicia; Bjørkøy, Geir; Pettersen, Kristine; Giambelluca, Miriam Soledad (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-07)
      Background To our current understanding, solid tumors depend on suppressed local immune reactions, often elicited by the interaction between tumor cells and tumor microenvironment (TME) components. Despite an improved understanding of anti-cancer immune responses in the TME, it is still unclear how immuno-suppressive TME are formed and how some cancer cells survive and metastasize.<p> <p>Methods ...

    • S100A8 gene copy number and protein expression in breast cancer: associations with proliferation, histopathological grade and molecular subtypes 

      Børkja, Mathieu; Giambelluca, Miriam Soledad; Ytterhus, Borgny; Prestvik, Wenche Slettahjell; Bjørkøy, Geir; Bofin, Anna M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-14)
      Background and aims Amplification of S100A8 occurs in 10–30% of all breast cancers and has been linked to poorer prognosis. Similarly, the protein S100A8 is overexpressed in a roughly comparable proportion of breast cancers and is also found in infiltrating myeloid-lineage cells, again linked to poorer prognosis. We explore the relationship between these findings.<p> <p>Methods We examined S100A8 ...

    • The third helix of the homeodomain of paired class homeodomain proteins acts as a recognition helix both for DNA and protein interactions 

      Bruun, Jack-Ansgar; Thomassen, Ernst I.s.; Kristiansen, Kurt; Tylden, Garth Daryl; Holm, Turid; Mikkola, Ingvild; Bjørkøy, Geir; Johansen, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2005)
      The transcription factor Pax6 is essential for the development of the eyes and the central nervous system of vertebrates and invertebrates. Pax6 contains two DNA-binding domains; an N-terminal paired domain and a centrally located homeodomain. We have previously shown that the vertebrate paired-less isoform of Pax6 (Pax6ΔPD), and several other homeodomain proteins, interact with the full-length ...

    • Transforming growth factor-beta-inducible early response gene 1 is a novel substrate for atypical protein kinase Cs 

      Alemu, Endalkachew; Sjøttem, Eva; Outzen, heidi; Larsen, Kenneth Bowitz; Holm, turid; Bjørkøy, Geir; Johansen, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      The protein kinase C (PKC) family of serine/threonine kinases consists of ten different isoforms grouped into three subfamilies, denoted classical, novel and atypical PKCs (aPKCs). The aPKCs, PKC?/? and PKC? serve important roles during development and in processes subverted in cancer such as cell and tissue polarity, cell proliferation, differentiation and apoptosis. In an effort to identify novel ...